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The plague is caused by a single gram-negative bacillus called Yersinia pestis, presenting in three distinct clinical manifestations depending on the site of infection. Bubonic plague develops when an infected flea transmits bacteria into subcutaneous tissue, migrating to regional lymphatics to produce agonizing, suppurative lymphadenitis known as buboes. Septicemic plague occurs when the pathogen enters directly into the bloodstream, triggering systemic endotoxemia, disseminated intravascular c
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