This is the first study to quantify an overall gene-level effect of FKBP5 in a GxE analysis of PTSD, evidence which may be used to address current issues in the FKBP5 GxE literature (e.g., disparate …

Jun 16, 2023 · The SNP rs9296158, located in the FKBP5 gene, has been identified as a risk factor for suicide after childhood trauma (31) and the severity of PTSD symptoms (132).

Jan 15, 2019 · A significant gene-level GxE gene effect was demonstrated for FKBP5 when pooled across all four examined variants (rs1360780, rs3800373, rs9296158, rs9470080) when interacting …

The FKBP5 gene has been implicated in the dysregulation of human stress responses, contributing to the risk and treatment response of stress-related disorders. The present study examined whether …

Summing up, rs1360780, a putative functional SNP of the FKBP5 gene, 30 has been shown to effect—in a PTSD disease status-dependent manner— FKBP5 gene expression and GR sensitivity.

Jul 1, 2016 · They further indicate that FKBP5 polymorphisms and childhood abuse may contribute to vulnerability for PTSD symptoms and may be most strongly associated with trauma-related …

Aug 5, 2021 · Post-traumatic stress disorder (PTSD) is a psychiatric disorder characterized by abnormal, prolonged stress response to a trauma. 1 Susceptibility to development of PTSD following exposure …

This pilot study aimed to expand research in this area by examining the relationship between DNA methylation of stress genes nuclear receptor subfamily 3 group C member 1 (NR3C1) and FK06 …

May 1, 2019 · FK506-binding protein 5 (FKBP5) binds to glucocorticoid receptors and modulates glucocorticoid sensitivity. The FKBP5 gene has been implicated in the dysregulation of human stress …

Sep 18, 2018 · Preliminary evidence in one small study suggests that FKBP5 methylation patterns may change in veterans with PTSD who respond to exposure therapy (24). Methylation influences …