For the first time since 2017, Real Madrid and Atlético Madrid are set to clash in the Champions League. Less than one month ago, Real Madrid and Atlético Madrid settled for a 1–1 draw for the second time in the 2024–25 La Liga season.

Real Madrid head coach Carlo Ancelotti will make four changes when his team faces crosstown foe Atletico Madrid in the Champions League last 16 on Tuesday.

The UEFA Champions League round of 16 officially begins this week as several European heavyweights begin to make their case to reach the May 31 final in Munich and win the whole thing. This round's action is headlined by the latest edition of the Madrid Derby as well as another regional matchup between Bayern Munich and Bayer Leverkusen.