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Orioles vs Astros Prediction, Odds, Picks - Aug. 21

Astros at Orioles Prediction: Odds, expert picks, starting pitchers, betting trends, and stats for August 21

Its Thursday, August 21 and the Astros (69-58) are in Baltimore to take on the Orioles (59-67). Jason Alexander is slated to take the mound for Houston against Brandon Young for Baltimore. Baltimore and Houston just met August 15-17 and the Orioles won two out of three against the Astros.

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Orioles vs. Astros Prediction, Odds, Picks - August 21

· 35m

Houston Astros at Baltimore Orioles odds, picks and predictions

· 10h

Cubs 4, Brewers 3: Milwaukee drops three straight for first time since May 7-10

On the heels of a disappointing doubleheader sweep, the Milwaukee Brewers look to get back on track against the Chicago Cubs at Wrigley Field on Wednesday night, Aug. 20.

· 11h

Twins vs. Athletics Prediction, Odds, Picks - August 21

· 8h

Phillies 11-2 Mariners (Aug 20, 2025) Final Score - ESPN

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Angels vs. Reds Prediction, Odds, Picks - August 20

The Angels are -126 moneyline favorites for this matchup with the Reds (+106).

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Blue Jays vs. Pirates MLB player props and odds - Tuesday, August 19

· 1d

Best MLB bets today: Astros vs. Tigers prediction, picks, props for August 19

Astros, Lance McCullers

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· 1d · on MSN

Houston Astros plan to start Lance McCullers Jr. against Baltimore on Friday

Lance McCullers Jr. has been on the injured list since July 22 with a blister on his finger but will return to pitch against the Orioles.

· 1d

Astros' Lance McCullers: Set to rejoin rotation Friday

· 1d

Astros announce Lance McCullers Jr. return date

· 17h

Mets Tabbed as Fit for Ex-Dodgers World Series Champ After Francisco Alvarez Injury

The New York Mets losing Francisco Alvarez to the injured list is a brutal blow, no doubt about it.

· 11h

Mets’ Brandon Nimmo leaves Nationals game early via injury

MLB · 15h

Correa delivers frank message on Astros' recent play after being swept

· 1d

Francisco Alvarez injury: Mets' starting catcher lands on IL, may require season-ending surgery

With Alvarez sidelined, the Mets will have no choice but to turn over their catching duties to veteran Luis Torrens and Senger.

· 13h

Padres Announce Jackson Merrill News After Leaving Dodgers Game

· 17h

Astros' Yordan Alvarez shares encouraging update after first rehab outing

CBSSports.com45m

Orioles' Dylan Beavers, Samuel Basallo eye home debuts vs. Astros

Orioles' Dylan Beavers, Samuel Basallo eye home debuts vs. Astros There finally is some buzz around the Baltimore Orioles again, with the combination of recent success and the arrival of new prospects creating interest. How that holds up against the ...

Sporting News on MSN2d

Sanchez robs two home runs, but Astros still lose 12-0 to Orioles

Jesus Sanchez had a night, robbing a grand slam and a three-run homer. Unfortunately for him, the rest of the team imploded.

3don MSN

Security tackles baseball fan after he ran onto field, interrupting Astros-Orioles game

A baseball fan stormed the field at Daikin Park and interrupted a game between the Houston Astros and Baltimore Orioles on Sunday afternoon.

3don MSN

Orioles’ young core explodes in 12-0 blowout win over Astros

Samuel Basallo had an eventful MLB debut, Dean Kremer shoved and the Orioles’ young core went off offensively in a 12-0 win over the Astros.

3don MSN

Jordan Westburg’s career-best 5 RBIs power Orioles to 12-0 rout of Astros

Jordan Westburg hit a three-run homer among four hits with a career-best five RBIs and Dean Kremer pitched seven sharp innings to give the Baltimore Orioles a 12-0 win over the Houston Astros.

Astros vs. Orioles Prediction, Odds, Picks - August 17

Preview the Aug. 17 matchup between the Houston Astros and Baltimore Orioles with odds over/under, game spread, betting lines and more.

4don MSN

Orioles lose marathon to Astros, 5-4, as Ramón Urías plays spoiler again

Ramón Urías capped off a wild extra-inning victory for the Astros over the Orioles with a walk-off grounder against his former team.

SB Nation on MSN3d

Shell-Shocked Astros Surrender to Orioles. Get bombed 12-0

Although the Astros went 3-3 on the homestand, they were outscored 44-17. Even when they play .500, the 2025 Astros seem lucky. They currently hold a one-game lead in the AL West, pending the Mariners’ nationally televised game later this evening.