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Orioles vs Astros Prediction, Odds, Picks - Aug. 21

Orioles vs. Astros Prediction, Odds, Picks - August 21

Preview the Aug. 21 matchup between the Baltimore Orioles and Houston Astros with odds over/under, game spread, betting lines and more.

ESPN · 1h

Astros vs. Orioles (Aug 21, 2025) Pregame - ESPN

Pregame analysis and predictions of the Houston Astros vs. Baltimore Orioles MLB game to be played on August 21, 2025 on ESPN.

Associated Press · 5h

Phillies vs. Mariners Picks, Odds and Prediction: Wednesday, Aug. 20

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Astros enter matchup with the Orioles

Sporting News on MSN · 2d

Sanchez robs two home runs, but Astros still lose 12-0 to Orioles

Jesus Sanchez had a night, robbing a grand slam and a three-run homer. Unfortunately for him, the rest of the team imploded.

Associated Press · 1h

Astros enter matchup with the Orioles on losing streak

Astros: Jason Alexander (3-1, 4.74 ERA, 1.33 WHIP, 35 strikeouts); Orioles: Brandon Young (1-6, 5.68 ERA, 1.49 WHIP, 46 strikeouts) BETMGM SPORTSBOOK LINE: Orioles -112, Astros -107; over/under is 9 runs BOTTOM LINE: The Houston Astros look to end their four-game skid with a victory over the Baltimore Orioles.

Fox Sports · 7h

Mariners take 4-game losing streak into matchup with the Phillies

Mariners: Luis Castillo (8-6, 3.48 ERA, 1.22 WHIP, 125 strikeouts); Phillies: Jesus Luzardo (11-6, 4.21 ERA, 1.34 WHIP, 158 strikeouts) BETMGM SPORTSBOOK LINE: Phillies -141, Mariners +119; over/under is 8 1/2 runs BOTTOM LINE: The Seattle Mariners,

3don MSN

Security tackles baseball fan after he ran onto field, interrupting Astros-Orioles game

A baseball fan stormed the field at Daikin Park and interrupted a game between the Houston Astros and Baltimore Orioles on ...

Astros make Cristian Javier announcement during Orioles game

The Orioles led 1-0 when Javier left the game, plating their only run on a sacrifice fly by Gunnar Henderson in the third.

3don MSN

Astros' Cristian Javier exits game against the Orioles because of an illness

Houston Astros starter Cristian Javier left Sunday’s 12-0 loss to the Baltimore Orioles after three innings because of an ...

Urìas beats throw to 1st to help the Astros outlast the Orioles, 5-4 in 12 innings

Ramón Urìas beat Jackson Holliday’s throw to first, allowing Carlos Correa to score from third and the Houston Astros ...

5don MSN

Ramón Urías was ‘in shock’ that Orioles traded him to Astros

I was actually in shock when Mike [Elias] called me,” Ramón Urías said of his trade from the Orioles to the Astros.

3don MSN

Jordan Westburg’s career-best 5 RBIs power Orioles to 12-0 rout of Astros

Jordan Westburg hit a three-run homer among four hits with a career-best five RBIs and Dean Kremer pitched seven sharp ...

4don MSN

The Houston Astros beat the Baltimore Orioles in 12 innings thanks to Ramón Urías

Ramón Urías beats out a potential double play to score Carlos Correa and give Houston a win in 12 innings over the Orioles.

3don MSN

Orioles lose marathon to Astros, 5-4, as Ramón Urías plays spoiler again

Ramón Urías capped off a wild extra-inning victory for the Astros over the Orioles with a walk-off grounder against his ...

5don MSN

Orioles right-hander Young loses perfect-game bid on infield single in the 8th inning vs Astros

Baltimore Orioles right-hander Brandon Young lost his bid for a perfect game against the Houston Astros on Friday night with ...

Astros vs. Orioles Prediction, Odds, Picks - August 17

Preview the Aug. 17 matchup between the Houston Astros and Baltimore Orioles with odds over/under, game spread, betting lines ...

3don MSN

Orioles’ young core explodes in 12-0 blowout win over Astros

Samuel Basallo had an eventful MLB debut, Dean Kremer shoved and the Orioles’ young core went off offensively in a 12-0 win ...

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