A new technology allows scientists to map, in single cells, the DNA binding sites of transcription factors and other ...

This image illustrates the process of gene transcription within a cell. The DNA double helix unwinds to expose a specific sequence, allowing RNA polymerase to synthesize a complementary pre-mRNA ...

D&D‑seq uses base editing to record DNA–protein interactions in single cells, enabling multiomics mapping of transcription ...

Living cells are fundamentally nonequilibrium systems, meaning they constantly spend energy through seemingly one-way, irreversible processes, such as transcribing DNA into RNA, to keep life going.

Transcription-coupled DNA damage repair represents a specialised branch of nucleotide excision repair that ensures rapid removal of lesions from the transcribed strand of active genes. When RNA ...

Transcription-coupled repair (TCR) represents a specialised subpathway of nucleotide excision repair that accelerates removal of lesions on the transcribed strand of active genes. In bacteria, DNA ...

Cell function is determined by how DNA is expressed into proteins. That process includes two main steps—transcription, when ...

Emerging gene editing platforms are revolutionizing precision medicine, enabling safe and effective genetic modifications for ...

While scientists have studied the molecular steps involved in gene expression for decades, many questions still remain about this fundamental process. To transcribe genes, RNA polymerase II (RNA Pol ...

Researchers working with the roundworm C. elegans have identified a feedback loop between two proteins that functions as a ...

Mobile DNA, once treated largely as genomic clutter, may help plants build new ways to respond to environmental stress.

The human heart must constantly adapt to changing demands—a task that requires tightly coordinated molecular shuffling in ...