San Francisco's defense was playing well Sunday, and came up with a big-time play to open the fourth quarter. Defensive end Sam Okuayinonu wrapped up WR Jaxon Smith-Njigba and forced a fumble that rookie safety Marques Sigle dove on for the takeaway. The 49ers desperately needed that after having a field goal blocked on their previous drive.

The San Francisco 49ers, led by quarterback Brock Purdy, face the Seattle Seahawks , led by quarterback Sam Darnold, on Sunday, Sept. 7, 2025 (9/7/25) at Lumen Field in Seattle, Washington.

Seattle Seahawks vs San Francisco 49ers picks, predictions, odds, win probabilities for NFL Week 1 Sunday football game on Sept. 7. Who will win game?

Had the Seahawks not rallied to beat the Cardinals, the discussion might have centered on why they are struggling defensively in the fourth quarter.

The Seattle Seahawks had some fun on social media after extending their winning streak over the Arizona Cardinals to eight games with a 23-20 victory on Thursday night.

The Seattle Seahawks set a franchise record with Jason Myers' 52-yard game winning kick against the Arizona Cardinals.

There is an NFC West matchup to open Week 4 of the NFL season on Thursday, Sept. 25 as the Arizona Cardinals host the Seattle Seahawks.

Kyler Murray feels like the first half was the biggest difference for the Arizona Cardinals in their 23-20 loss to the Seattle Seahawks on Thursday night.

Seahawks quarterback Sam Darnold and his top target, Jaxon Smith-Njigba, came through in the clutch to help the Seahawks to a 23-20 win in Arizona.