Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting the upper and lower motor neurons. A key clinical feature of ALS is the absence of accurate, early-stage ...

Dr Th Postert, Department of Neurology, St Josef Hospital, Ruhr-University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany. OBJECTIVES AND METHODS Transcranial real time sonography (TCS) was applied ...

Dr L J Balcer, 3E Gates Building-Neurology, 3400 Spruce Street, Philadelphia, PA 19104, USA; lbalcer{at}mail.med.upenn.edu Objective: To examine the relation between low contrast letter acuity, a new ...

Correspondence to Dr Benedict Daniel Michael, University of Liverpool Institute of Infection and Global Health, Liverpool L69 3BX, UK; benmic{at}liv.ac.uk Clinicians are increasingly recognising ...

Aims and Hypothesis We propose a medical hypothesis on pathophysiology of psychogenic polydipsia in psychiatric patients. Background Compulsive behaviours, which aim to reduce distress, are common in ...

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Six patients are described who experienced difficulty in driving a motor car. Four had illusions that the car was turning, which occurred particularly on open, featureless roads or the brows of hills ...

Background Increased rates of brain atrophy on serial MRI are frequently used as a surrogate marker of disease progression in Alzheimer’s disease and other dementias. However, the extent to which they ...

Identifying biomarkers of Alzheimer’s disease (AD) will accelerate the understanding of its pathophysiology, facilitate screening and risk stratification, and aid in developing new therapies.

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The concept of antibody mediated CNS disorders is relatively recent. The classical CNS paraneoplastic neurological syndromes are thought to be T cell mediated, and the onconeural antibodies merely ...

In the management of neurological diseases, the identification and quantification of axonal damage could allow for the improvement of diagnostic accuracy and prognostic assessment. Neurofilament light ...