A pharmaceutical milestone seems to have been reached last month when a National Cancer Institute panel approved an anti-tumor drug called PS-341 for government-financed clinical trials. PS-341 is the ...

Ubiquitin marks proteins for degradation, whereby ubiquitin molecules can be combined in different types and numbers forming different chains. Researchers at the Max Planck Institute of Biochemistry ...

Last May, the US Food and Drug Administration approved the first weapon in what could become a brand new arsenal against cancer. That weapon is Velcade (bortezomib), a drug that inhibits an ...

Maintaining cellular order is a major logistical challenge: Individual mammalian cells contain billions of protein molecules, ...

Technion professors Avram Hershko and Aaron Ciechanover won a Nobel Prize in 2004 for their discovery of ubiquitin, which ...

Genes & Diseases is a journal for molecular and translational medicine. The journal primarily focuses on publishing investigations on the molecular bases and experimental therapeutics of human ...

A new editorial paper was published in Oncoscience (Volume 11) on May 6, 2024, entitled, "Restoring our ubiquitination machinery to overcome resistance in cancer therapy." In this new editorial, ...

This is a preview. Log in through your library . Abstract The reversibility of ubiquitination by the action of deubiquitinating enzymes (DUBs) serves as an important regulatory layer within the ...

Vol. 69, No. 19, Special Issue: Orchestrating the Proteome with Post-Translational Modifications (August 2018), pp. 4529-4537 (9 pages) The ubiquitin–proteasome system (UPS) has been shown to play ...