Scientists reveal splicing-based mechanism driving therapy resistance in pediatric acute myeloid leukemia by Chinese Academy of Sciences edited by Sadie Harley, reviewed by Robert Egan Editors' notes ...

Alternative splicing is a fundamental mechanism by which precursor messenger RNA (pre-mRNA) transcripts are variably processed to yield multiple mature mRNA isoforms from a single gene. This process ...

Researchers confirm that the established pre-mRNA splicing mechanism that appears in textbooks cannot work in a subset of human short introns: A novel SAP30BP–RBM17 complex-dependent splicing has been ...

Spatial transcriptomics has advanced the study of gene expression in tissues, but most current approaches rely on 3′-end sequencing and provide limited information on alternative splicing (AS).

Alternative splicing is a genetic process where different segments of genes are removed, and the remaining pieces are joined together during transcription to messenger RNA (mRNA). This mechanism ...

A recent study highlights the pivotal role of alternative splicing in controlling plant secondary metabolism, which is crucial for producing bioactive compounds with significant medicinal and ...

Genes contain the essential building instructions for life, guiding cells on which amino acids to assemble in what sequence to produce specific proteins. The human genome codes for about 20,000 such ...

This article was review by Thomas Cooper, MD from Baylor College of Medicine. Stay up to date on the latest science with Brush Up Summaries. Despite its significance, alternative splicing’s global ...

Type-II diabetes is a chronic disease caused by insulin resistance due to pancreatic β-cell dysfunction. Mutations in a single gene, HNF1A, which codes for the transcription factor hepatocyte nuclear ...

Pediatric acute myeloid leukemia (AML) is one of the most common acute leukemias in children. While treatment outcomes have improved in recent years, approximately 30% of patients relapse following ...