Researchers in Class of 1942 Professor of Chemistry Matthew D. Shoulders' lab have uncovered a sinister hidden mechanism that ...

Protein folding is a critical process by which linear chains of amino acids adopt specific three‐dimensional conformations essential for biological function. In recent years, studies have increasingly ...

For those outside the chemistry cognoscenti, the announcement might have seemed little more than researchers patting each other on the back. But the question of protein folding had plagued scientists ...

Proteins are long molecules that must fold into complex three-dimensional structures to perform their cellular functions. This folding process occasionally goes awry, resulting in misfolded proteins ...

Edited by: James Kling K.A. Dill, S. Bromberg, K.Z. Yue, K.M. Fiebig, D.P. Yee, P.D. Thomas, H.S. Chan, "Principles of protein-folding-a perspective from simple exact ...

Cellular membrane proteins play important roles in cellular transport, signaling, and cell-to-cell communication. Malfunction in membrane proteins can lead to serious diseases, such as cancer. However ...

Textbooks often depict proteins in one conformation, but real life, as usual, is much messier. While some proteins have stable, unchanging structures, many others have intrinsically disordered regions ...

In order to fulfil their many functions, proteins must be folded into the correct shape. Researchers at the University of Basel have now discovered tiny “folding factories” in cells that enable ...

A GIF showing a protein mimicking IL-2 binding to IL-2 receptors, then changing shape in response to an effector molecule, which forces it off of one of the receptors. A protein mimicking IL-2 called ...

I read with interest your report on protein folding.1 You cited C. Levinthal, Journal of Chemical Physics, 65:44-5, 1968 to illustrate the difficulty in the folding problem: "[Levinthal's paradox] ...