By extending a naturally rigid bacterial protein by 50% while preserving geometry and stability, the study introduces protein ...

No gene acts alone: interacting variants and protein partnerships can worsen, mask or even rescue disease risk, demanding ...

The way proteins move is often what gives them biological activity: they can open, close, twist, and rearrange themselves in ways that allow them to bind to other molecules or perform complex ...

Misfolded proteins can appear as small aggregates, soluble monomers, or large insoluble inclusion bodies. While the fundamental biophysical mechanisms that cause cytotoxicity are not fully understood, ...

Illustration showing how integrating protein three-dimensional structures with artificial intelligence algorithms can predict synergistic or antagonistic effects of drug combinations, guiding safer ...

The strategies biopharmaceutical manufacturers currently use to limit protein misfolding are complex, time-consuming, and generate low yields with only limited scalability. Covalent organic frameworks ...