Vaults are massive ribonucleoprotein complexes, highly conserved and abundant in eukaryotic cells, yet with unclear function. Their thin-walled barrel-shape architecture is composed of two symmetrical ...

The cells of higher organisms such as mammals, flies and fungi enclose their genetic material in a nucleus. A nuclear ...

The nuclear pore complex (NPC) is a large multiprotein assembly embedded within the nuclear envelope of eukaryotic cells. Comprising around thirty distinct nucleoporins arranged into structural ...

Nuclear pore complexes (NPCs) are channels composed of multiple proteins that ferry molecules in and out of the nucleus, regulating many critical cellular functions, such as gene expression, chromatin ...

ETH Zurich researchers have revealed how the enzyme Torsin-1A and the CLCC1 complex fuse the nuclear envelope to build ...

Just as cities must carefully manage the flow of cars in and out of downtown, cells regulate the movement of molecules into and out of the nucleus. This microscopic metropolis relies on an intricate ...

The genome of complex organisms is stashed away inside each cell’s nucleus, a little like a sovereign shielded from the threatening world outside. The genome cannot govern from its protective chamber, ...

Nuclear pore complexes are more dynamic than previously thought, reshaping our understanding of a vital transport process in cells. An international study led by the University of Basel (Switzerland) ...

When it comes to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and certain forms of dementia, researchers have known that protein quality control and damage to the nuclear ...

Nuclear pore complexes (NPCs) are channels composed of multiple proteins that ferry molecules in and out of the nucleus, regulating many critical cellular functions, such as gene expression, chromatin ...