The Arizona Cardinals were not the NFL's most talented team during the second year of coach Jonathan Gannon's tenure, but they were among the most disciplined, committing the league's second-fewest penalties in 2024.

Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale.

Arizona Cardinals head coach Jonathan Gannon says talk of him being on the 'hot seat' as far as his job comes with being an NFL head coach.

Setting NFL records is cool - but winning is much cooler in the eyes of Arizona Cardinals QB Jacoby Brissett. In the process of being routed by the San Francisco 49ers in Week 11, Brissett set an NFL record with 47 pass completions today. Brissett, when speaking with reporters after the loss, says he couldn't care less.

SANTA CLARA, Calif. (AP) — Brock Purdy returned to the lineup and the San Francisco 49ers scored their most points in nearly two years. While Purdy looked sharp in the 41-22 victory over the Arizona Cardinals on Sunday, the reasons behind the big scoring output have to do with a lot more than just the change at quarterback.

Brock Purdy returned from a six-game absence to throw three touchdowns as the 49ers (7-4) romped to a 41-22 win over the host Cardinals (3-7).

The Arizona Cardinals quarterback, who is filling in for the injured Kyler Murray, completed 47 of his 57 pass attempts, setting a new record for completions in a single game. Drew Bledsoe had 45 completions in 1994, and Jared Goff had the same mark in 2019.

Cardinals 2026 NFL Draft mock: Every pick, potential starters, and the moves that could reshape the team. The season feels all but over for the Arizona Cardinals, and fans are ready for the offseason.

Dallas looks to snap its two-game losing streak against struggling Las Vegas at Allegiant Stadium, with kickoff set for 8:15 p.m. ET on ABC/ESPN. Here's how to watch for free.

Christian McCaffrey National Football League San Francisco 49ers Top Plays NFL - San Francisco 49ers vs. Arizona Cardinals - 11/16/2025