A new treatment platform developed by researchers at the University of Texas MD Anderson Cancer Center was able to deliver ...

Skeletal muscle is a highly organised and multifunctional tissue composed of myofibrils that generate movement through coordinated contractile force. Its architecture integrates vascular, neural, and ...

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

Myotonic dystrophy type 1 (DM1) is the most common form of adult-onset muscular dystrophy, affecting about 1 in 8,000 people. While it is well known for causing muscle weakness and stiffness, DM1 also ...

The same model also allows exploration of CICR in neurons, smooth muscle, and immune cells, expanding its clinical impact. With this insight, drug design can now focus on precision control of Ca²⁺ ...

Can you explain what Myomaker Bio's lab-grown human muscle platform is and the challenge it aims to address in drug development? Myomaker Bio develops three-dimensional human-derived muscle organs and ...

The “atrofish” reveals early triggers of sarcopenia and links muscle loss to nerve degeneration, establishing a platform for comparative research on muscle aging and potential therapies As people age, ...

Muscle stem cells (MuSCs) are essential for nearly all aspects of muscle biology, orchestrating muscle growth, maintenance, and repair. PAX7 is the canonical marker of MuSCs in most vertebrates and is ...

Engineered extracellular vesicles delivering full-length DMD mRNA restored dystrophin and improved muscle strength and ...