For each IGHV gene, a segment of sequence was selected as a marker for detection, given that specific primers and probes could be designed from that sequence. Single sperm samples were prepared by ...

We used CLL cell DNA to detect the mutation status of both the productive and nonproductive IGHV rearrangements present in leukemic cells in a prospectively ascertained CLL cohort with treatment and ...

SEATTLE, Sept. 30, 2021 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (Nasdaq: ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune ...

The BCR IGH is coded for by multiple genes, including VDJ genes. Only productive and functional IG rearrangements are retained in B-cells. IGH gene rearrangements in B-cells undergo additional somatic ...

Please provide your email address to receive an email when new articles are posted on . Most patients with chronic lymphocytic leukemia who received ibrutinib plus fludarabine, cyclophosphamide and ...

Javier Pinilla-Ibarz, MD, PhD: In terms of diagnosis and prognosis for chronic lymphocytic leukemia, we initially have to perform a technique called flow cytometry that will really indicate the ...

MILAN — Is chronic lymphocytic leukemia (CLL) progression primarily driven by genetic mutations or by external cues from the tumor microenvironment? Despite major strides in targeted therapies, CLL ...

Young patients with chronic lymphocytic leukemia (CLL) can enjoy long remissions on the drug ibrutinib, but must stay on it indefinitely to keep the cancer in remission. A new study by Dana-Farber ...

NOTCH1 mutations, found in 20% of CLL cases, are associated with poor outcomes in chemotherapy but not yet in treatment guidelines. A retrospective analysis showed improved PFS for NOTCH1-mutated CLL ...

The Germinal Center/Activated B-Cell Subclassification Has a Prognostic Impact for Response to Salvage Therapy in Relapsed/Refractory Diffuse Large B-Cell Lymphoma: A Bio-CORAL Study There were 930 ...

Combined ID-IGHV report at time of diagnosis conveniently provides additional prognostic information while also enabling future MRD monitoring in patients SEATTLE, Sept. 30, 2021 (GLOBE NEWSWIRE) -- ...