Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which garnered a Nobel Prize in 1953, brought into clear view structures inside ...

Cryo-electron microscopy (cryo-EM) can help scientists determine the three-dimensional structure of proteins in unprecedented detail. Jacques Dubochet, former group leader at EMBL, shared the 2017 ...

Healthy cells are constantly breaking down proteins and building up new ones with the help of enzymes aptly named unfoldases, because they unravel proteins tagged for destruction or recycling. Now, a ...

Traditional electron microscopy techniques include scanning electron microscopy (SEM) and transmission electron microscopy (TEM), where electrons that interact with the sample are imaged. 4 The ...

TEM works by accelerating electrons, typically with energies between 80 and 300 kV, and directing them through a specimen thin enough for electron transmission. Because of their very short wavelength ...

Electron microscopy is a powerful technique that provides high-resolution images by focusing a beam of electrons to reveal fine structural details in biological and material specimens. 2 Because ...

The scanning electron microscope (SEM) delivers high resolution, high depth of field, and an image quality as if microscopic objects are seen by the naked eye. This makes it not only a powerful ...

Electron microscope (EM) has revolutionized our ability to visualize the intricate details inside cells. The advancement to 3D electron microscopy, known as volume EM (vEM), has further expanded this ...

The integration of machine learning (ML) models enhances the efficiency, affordability, and reliability of feature detection in microscopy, yet their development and applicability are hindered by the ...

Scanning transmission electron microscopy, or STEM, is a powerful imaging technique that enables researchers to study a material’s morphology, composition, and bonding behavior at the angstrom scale.

Schematic diagram and photograph showing the ultrafast transmission electron microscopy integrated with transient optical spectroscopy capability, enabling co-registered measurements of electronic and ...