Expert Rev Clin Pharmacol. 2010;3(3):321-329. Torsades de pointes (TdP) arrhythmia is a potentially life-threatening cardiac disorder that is often associated with a prolonged QT interval in the ...

We report here that both PBMNC and PBCD34 + cells do not express herg, which is however rapidly up-regulated in the latter upon induction of proliferation by cytokines/growth factors. Moreover, this ...

The EIT–EVA PCB sensor setup used to evaluate the effects of drugs on hERG channels. The sensor measures changes in extracellular resistance as voltage-gated hERG channels are activated and inhibited, ...

MHRA has made the company a member of the UK GLP compliance monitoring programme MHRA has made the company a member of the UK GLP compliance monitoring programme Metrion Biosciences, a company focused ...

Somehow a drug has turned into a political tool. This is nuts. Hydroxychloroquine may or may not end up having any utility as a COVID-fighting drug. But its cardiac toxicity is real, unlike the ...

Metrion Biosciences Limited (“Metrion”), the specialist ion channel contract research and drug discovery company, today announced it has received notification from the UK’s Medicines and Healthcare ...

Currently, only 10% of the drugs that enter Phase I receive marketing approval from the U.S. Food and Drug Administration (FDA), with unmanageable toxicity accounting for approximately 30% of the ...

Our lab studies the physiology, pharmacology and biophysics of ion channels. Ion channel proteins form ion-selective pores within cell membranes and in the heart they establish and maintain normal ...

New York, NY, Jan. 16, 2024 (GLOBE NEWSWIRE) -- Polaris Market Research has published a recent study report titled "HERG Screening Market Share, Size, Trends, Industry Analysis Report, By Product Type ...

Scientific research has given us a fairly good, and still continuously improving, knowledge about TdP and other cardiac arrhythmias and malfunctions and their molecular causes. These understandings ...

Metrion Biosciences Limited (“Metrion”), announced it has received notification from the UK’s Medicines and Healthcare products Regulatory Agency (MHRA) that the Company is now a member of the UK GLP ...