If you are anything like us, whenever you plan a journey, you spend a remarkable amount of time thinking about the start and ...

Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...

Eukaryotic chromosomes replicate from multiple discrete loci termed origins of replication. These sites are first recognised by the origin recognition complex (ORC), which, together with Cdc6 and Cdt1 ...

Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...

Researchers shed new light on G-quadruplexes, a type of secondary DNA structure that has attracted attention as a potential therapeutic target in cancer. Every day, billions of cells in your body ...

Despite extensive studies on DNA replication, the exchange mechanisms of DNA polymerase during replication remain unclear. Existing models propose that this exchange is facilitated by protein partners ...