A study shows epigenetic proteins regulate genes through diverse dynamic patterns, not simple on-off control, with each ...

Researchers have shown that different epigenome proteins can produce distinct gene expression patterns from the same gene, offering new insights into genetic regulation. The findings could help ...

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

A study published in the journal Cell marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells.

A new study finds the proteins responsible for controlling which genes are expressed in a genome do more than simply turn a ...

Spinal translational control mechanisms regulate gene expression and nociceptive circuit sensitization during the chronic phase of neuropathic pain.

Our circadian clocks play a crucial role in our health and well-being, keeping our 24-hour biological cycles in sync with light and dark exposure. Disruptions in the rhythms of these clocks, as with ...

CRISPR-Cas9 has been widely adapted for use in transcriptional modulation and epigenetic engineering with deactivated Cas9 (dCas9) systems to enable CRISPR interference (CRISPRi) and CRISPR activation ...

A collaborative effort has shed valuable light on how monoamine neurotransmitters such as serotonin, dopamine, and now histamine help regulate brain physiology and behavior through chemical bonding of ...

To help achieve more precise control of gene therapy, engineers have designed a new control circuit that can keep gene expression levels within a target range. The method could be used to deliver ...