Louisville is favored by three points against Clemson, per the VegasInsider.com consensus betting line. The point spread opened at Louisville -2.5 and has ticked up slightly. This is Clemson’s first time as a betting underdog this year. ESPN gives Louisville a 54.9% chance of winning.

The Clemson Tigers have their share of stars in the NFL, but a few more are starting to take their game to another level

Kickoff from L&N Federal Credit Union Stadium in Louisville, Ky., is at 7:30 p.m. ET. The Cardinals are 1.5-point favorites in the latest Clemson vs. Louisville odds, while the over/under for total points scored is 50.5. Before making any Louisville vs. Clemson picks, check out the college football predictions from the SportsLine Projection Model .

Klubnik, the Tigers’ senior starting quarterback, rolled his ankle during an Oct. 4 win at Boston College. He missed Clemson’s next game (an Oct. 11 home loss to SMU) and was replaced by backup quarterback Christopher Vizzina.

Our Clemson vs. Louisville predictions think Jeff Brohm will have the Cardinals ready to bounce back after an ugly loss on Saturday night.

Dabo Swinney is having his worst season at Clemson. Here's how his son Clay Swinney and other Tigers players described the season.

Clemson Tigers football head coach Dabo Swinney was screaming so loudly at his players that you could partially hear it on the live ESPN broadcast. The Tigers suffered a heartbreaking 46-45 loss to the visiting Duke squad on Saturday, dropping them to 3-5 ...

Duke QB Darian Mensah threw a pass incomplete on 4th and 10 from Clemson’s 18, but refs flagged Clemson for pass interference and an automatic first down. Boos rained down and Clemson coach Dabo Swinney was beside himself.

Here is everything you need to know about watching college football on Saturday, including TV and streaming information for the entire Week 12 slate.