Nov 16, 2025; Glendale, Arizona, USA; San Francisco 49ers quarterback Brock Purdy (13) throws the ball while Arizona Cardinals defensive lineman Walter Nolen III (97) defends in the first half at State Farm Stadium. Mandatory Credit: Matt Kartozian-Imagn Images / Matt Kartozian-Imagn Images

When Jonathan Gannon took over as coach of the Arizona Cardinals he laid out key expectations. But the team is again mired in a disappointing season.

The 49ers' team captains stepped up in Arizona. One of them, George Kittle, said the team is positioned right where it needs to be.

Sep 25, 2025; Glendale, Arizona, USA; Arizona Cardinals quarterback Kyler Murray (1) looks to pass against the Seattle Seahawks in the second quarter at State Farm Stadium. Mandatory Credit: Joe Camporeale-Imagn Images / Joe Camporeale-Imagn Images

The most notable is the team franchise record set by the Cardinals for most penalties, with 17 for a total of 130 yards, surpassing the previous record set in 1936. 11 of those penalties came in the first half, which was more points than the team scored in the first half.

The Arizona Cardinals set a franchise record with 17 penalties during their latest loss, a 41-22 disaster vs. the 49ers, and it could prove costly.

The NFL is full of surprises. For the Arizona Cardinals and plenty of fans around the country, they received some notable news on Wednesday morning that will shake up their plans for game day. Marvin Harrison Jr.

With the activation of linebacker BJ Ojulari from PUP Saturday and the addition of linebacker Mack Wilson Sr. to IR, the Cardinals now have 13 players placed on IR since the cut to 53, three on IR prior to the cut to 53 and one, cornerback Sean Murphy-Bunting, on reserve/non-football injury, also done prior to the reduction to 53.