The coffee paradox in adenosine-mediated antidepressant action. Depression (left) and coffee consumption (right) are both linked through adenosine signaling (center), creating a pharmacological ...
Five signaling subtypes identified by NMF clustering. Subtype 5 (high APsig) correlates with immune-rich "hot" tumors, while Subtype 2 (low APsig) exhibits metabolic reprogramming and hypoxia. High ...
Adenosine Signaling: Convergent Mechanisms for Rapid Antidepressants. Three distinct interventions—ketamine (pharmacological), electroconvulsive therapy/ECT (electrical), and acute intermittent ...
Perhaps the most intriguing implication of recent breakthrough research lies in an unexpected connection: the most rigorous mechanistic dissection of rapid antidepressant action identifies adenosine ...
(RTTNews) - Corvus Pharmaceuticals Inc. (CRVS) announced new data highlighting the potential of ciforadenant, the Company's adenosine A2A receptor antagonist, to overcome resistance to anti-PD1 ...
The 8-Bromo-cAMP sodium salt PKA activator, a synthetic analog of cAMP, is one of the most potent tools of investigating and playing with this pathway, which has become an essential part of ...
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