To win the largest lottery prize of the year so far, a Powerball ticket buyer has to overcome astronomical odds of 1 in 292.2 million.

This marks the 10th time that a Mega Millions lottery jackpot was won in Virginia since the game launched 23 years ago

The Powerball jackpot climbed to $643 million after no one matched all the winning numbers in Monday's drawing. Here's how to play ahead of Wednesday's drawing.